The availability and applicability of current donor, autologous and synthetic prostheses hinder the therapeutic replacement of diseased tubular tissues. Constructs created artificially and made by tissue engineering have the potential to alleviate autoimmune reactions, improve anatomical accuracy, and achieve long-term patency and growth, which can alleviate these problems. The emergence of biological 3D printing technology has further supplemented the technical toolbox, opened up new opportunities for biological manufacturing research, and expanded the therapeutic potential in this field.
Recently, the Liu Dongsheng team in Tsinghua University published a summary entitled 3D Biofabrication for Tubular Tissue Engineering in Bio-Design and Manufacturing, focusing on the challenges faced in trying to construct artificial tubular tissues with corresponding complex macro and micro structures, reviewing the current biological manufacturing methods including 3D printing technology, and proposing the future development direction.
Fig. 1 tissue engineering process of tubular organs using acellular animal donor tissue
Fig. 2 tissue engineering method for manufacturing tubular organs
Fig. 3 3D printing method for manufacturing tubular organs by biological augmentation
Links to papers:
Bio-Design and Manufacturing(BDM), a professional English quarterly newly created by Zhejiang University in 2018, has been retrieved by SCI-E and others. The first impact factor in 2020 is expected to be above 3 points. The preliminary examination lasted for 3-4 days, and the average employment time was about 40 days.
Receiving directions: mechanical engineering (3D printing and biological processing engineering, etc.), biological ink and formulation, tissue and organ engineering, medical and diagnostic devices, and biological product design
Journal home page:
Http://www.jzus.zju.edu.cn/ (Full Text Downloadable in China)
Online submission address: