Three-dimensional (3D) printed scaffolds have received considerable attention in recent years because they provide the right environment for the regeneration of bone cell tissue and can be customized to shape.Among many challenges, the material composition and geometry have a significant impact on the performance of the scaffold.Hydroxyapatite and tricalcium phosphate (HA/TCP), as the main components of natural bones and teeth, have good biological properties and are widely used in the manufacture of bone scaffolds.Many manufacturing methods have been studied to attempt to obtain HA/TCP scaffolds with microporous structures to facilitate cell growth and nutrient transport.However, the current 3D printing method can only realize the HA/TCP scaffold with a certain range of microporous structure.
Recently, the university of southern California Yong Chen et al., in the Bio – the Design and Manufacturing published on 3 d printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for ipads regeneration, and developed based on the size of the micro stereo lithography mask image projection,This enables us to obtain HA/TCP based photocured suspensions with complex geometry including bionic features and layered porosity.Here, we investigated the curing properties and physical properties of HA/TCP suspensions and developed a circular motion process for the manufacture of high viscosity HA/TCP suspensions.Based on these studies, we optimized the scaffold composition.We believe that 30 wt% HA/TCP scaffolds with biomimetic layered structure exhibit excellent mechanical properties and porosity.We studied cell proliferation in vitro and performed surgery in an in vivo model of nude mice with long bone with cranial neural crest cells and bone marrow mesenchymal stem cells.The results show that the 3D printed HA/TCP scaffold with bionic layered structure is biocompatible and has sufficient mechanical strength for surgery.
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About the BDM
Bio-design and Manufacturing (BDM), a professional English quarterly newly created by Zhejiang University in 2018, has been indexed by SCI-E et al., and the first impact factor is expected to be more than 3 points in 2020.The preliminary examination lasts 3-4 days, and the average employment time is about 40 days.
Direction: Mechanical engineering (3D printing and biological treatment engineering, etc.), bio-ink and formulation, tissue and organ engineering, medical and diagnostic equipment, biological product design
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